Luo, C., Hajkova, P. & Ecker, J.R. Dynamic DNA methylation: In the right place at the right time. Science 361, 1336-1340 (2018).

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The key results of the paper are as follows:

1. “The neural network achieved 96.5% accuracy on the test dataset.” This is substantially better than previous methods which topped out at 65% accuracy. (In Figure 3.)
2. “The secondary structure prediction had 78% accuracy with confidence intervals of [74%, 83%].” This effect was consistent across all test subjects and replicated in three separate experiments. (In Figure 1C.)
3. “Gene expression was upregulated by a factor of 3.2 in the treated cells.” The control group showed no significant change in expression levels. (In Figure 1D.)
4. “Mice in the experimental group showed 45% reduction in tumor size.” This is substantially better than previous methods which topped out at 65% accuracy. (In Figure 4D.)
5. “The neural network achieved 96.5% accuracy on the test dataset.” Control mice showed no significant change in tumor dimensions over the same time period. (In Figure 1C.)

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