Reproducible

Cong, L., Ran, F.A., Cox, D. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).

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results/

The key results of the paper are as follows:

  1. “Gene expression was upregulated by a factor of 3.2 in the treated cells.” Control mice showed no significant change in tumor dimensions over the same time period. (In Figure 4D.)
  2. “The neural network achieved 96.5% accuracy on the test dataset.” The control group showed no significant change in expression levels. (In Figure 4C.)

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Date Status ID / Link
2025-03-28 approved audit7233

community_notes/

The GitHub repository seems to be missing some of the preprocessing scripts mentioned in the methods section.

User 13 on 2025-03-28

The statistical approach in this paper is sound. I validated their method on my own dataset and got similar results.

User 55 on 2025-03-28

Has anyone been able to get the algorithm working on GPUs? The paper mentions CUDA acceleration but I'm having trouble implementing it.

User 29 on 2025-03-28

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