Brouwer, P.J.M., Caniels, T.G., van der Straten, K. et al. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability. Science 369, 643-650 (2020).

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The key results of the paper are as follows:

1. “Mice in the experimental group showed 45% reduction in tumor size.” Control mice showed no significant change in tumor dimensions over the same time period. (In Figure 3C.)
2. “The secondary structure prediction had 78% accuracy with confidence intervals of [74%, 83%].” Control mice showed no significant change in tumor dimensions over the same time period. (In Figure 2.)
3. “Gene expression was upregulated by a factor of 3.2 in the treated cells.” Control mice showed no significant change in tumor dimensions over the same time period. (In Figure 1B.)
4. “The secondary structure prediction had 78% accuracy with confidence intervals of [74%, 83%].” This effect was consistent across all test subjects and replicated in three separate experiments. (In Figure 2B.)
5. “We observed a significant effect (p < 0.01) between treatment and control groups.” This represents a 15% improvement over the previous state-of-the-art approach. (In Figure 2C.)
6. “We observed a significant effect (p < 0.01) between treatment and control groups.” The control group showed no significant change in expression levels. (In Figure 4A.)

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